GSH reduces NAPQI, the metabolite responsible for hepatotoxicity in acetaminophen toxicity. Toxic doses increase oxidation into NAPQI, overwhelming glutathione. How does ethanol interfere with acetaminophen metabolism? Image: https: t.co 6EY9dIwLXY Glutathione, Alcohol and drugs Acetaminophen's Role in Autism and ADHD: A Mitochondrial Perspective About Acetaminophen Overdose Glutathione: Master Antioxidant, Reducing Oxidative Stress, and Detoxification A Possible Antidote for Tylenol (Paracetamol) Overdose American Council on Science and Health