The role of NAD+ metabolism and its modulation of mitochondria in aging and disease npj Metabolic Health and Disease NAD vs Glutathione: What's the Difference? L Glutathione At Home Buy L Glutathione Home Injections NAD vs Glutathione: Key Differences and Benefits Explained Goldman Glutathione (GSH) and NAD are both critical for cellular health, energy, and repair. Yet, they function very differently in the body. The question I'm often asked is, "Which one do I need Biochemical redox (reduction and oxidation): what, how, why, NAD+ NADP+, glutathione, ox #, etc.