Sex differences in glutathione metabolism and acetaminophen toxicity View of Acetaminophen, the missing anion gap in the patient with metabolic acidosis The Southwest journal of medicine Tylenol, Autism, And The Glutathione Connection OC Integrative Medicine Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Acetaminophen at low doses depletes airway glutathione and alters respiratory reflex responses Smith 2013 The FASEB Journal Wiley Online Library Let's talk Tylenol Paracetamol (acetaminophen) There are many side effects that most people don't realize. OTC does not mean it is side effect free, especially with chronic use. Even just 4 days of